The Cobras got a no-hit shutout from starting pitcher Tyler McLeod, who struck out four and walked only two.
Mack Smith homered twice for the Cobras, both shots with a runner on base. Jase Alexander doubled and had two singles.
Earlier in the week, at Hazlehurst, the Cobras blasted the Indians 16-0 in four innings.
Wesson finished region play with a sweep of Jefferson County on Tuesday, improving to 13-11 and completing a perfect region slate at 10-0.
The Cobras traveled to Magee on Tuesday to wrap up the regular season and will have a bye in the opening round of the 3A playoffs.